![]() Blood pressure and heart rate decreased with an increasing dose of anesthetic. Significant differences among isoflurane MAC multiples were observed for HR, mean, diastolic, and systolic blood pressures. There were no significant differences in any of the cardiovascular variables between the treatments. Data were analyzed using a two-way analysis of variance for repeated measures looking for differences between treatments and among MAC multiples. At 1.0 and 2.0 MAC, simultaneous blood samples were drawn from the tail vein/artery complex and femoral catheter for blood gas analysis. At each concentration, the heart rate, blood pressure (systolic, mean, diastolic), end-tidal CO2, and SpO2 were measured. The treatment was administered, and the animals were equilibrated for 20 minutes at each MAC multiple. Body temperature was stabilized and maintained at 32 degrees C. Instrumentation included use of an ECG, airway gas monitor, cloacal thermometer, esophageal pulse oximeter, and the placement of a femoral arterial catheter. Anesthesia was induced with isoflurane and maintained using controlled ventilation. The iguanas were exposed to each of the three minimum alveolar concentration (MAC) multiples (1.0, 1.5, and 2.0) in random order. Treatments were separated by at least 1 week. The iguanas received each of two treatments, saline 0.1 mL kg(-1) (SAL) and butorphanol 1.0 mg kg(-1) (BUT) during isoflurane anesthesia. Six mature healthy green iguanas (Iguana iguana). Prospective randomized double-blind, two-period cross-over trial. To assess the cardiovascular effects (arterial blood pressure, heart rate, and metabolic acid-base status) of three doses (MAC multiples) of isoflurane alone and combined with butorphanol in the green iguana (Iguana iguana). ![]() To the authors' knowledge, the present is the first report evaluating a PCA in the rabbit. Limits of agreement provided for each variable allow researchers to evaluate if the PCA is reliable enough for their scope. The current study provides sufficient evidence that the PCA presents reliability for pH, although its low agreement with a reference analyzer for the other variables does not support their interchangeability. Most variables presented significant proportional and/or constant bias. Limits of agreement were wide for all the variables studied, with the exception of pH. Bland-Altman plots and Passing-Bablok regression analysis were used to compare the results. Blood samples obtained from 30 pet rabbits were analyzed immediately after collection by the portable clinical analyzer (PCA) and immediately thereafter (time <20 sec) by a reference analyzer. ![]() The purpose of this study was to evaluate the performance of a portable clinical analyzer for measurement of pH, partial pressure of CO2, Na, chloride, potassium, blood urea nitrogen, glucose, hematocrit, and hemoglobin in healthy and diseased rabbits. Point-of-care testing is an attractive option in rabbit medicine, because it permits rapid analysis of a panel of electrolytes, chemistries, blood gases, hemoglobin, and hematocrit, requiring only 65 μL of blood. ![]()
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